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Updated: Sep 10, 2025

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

Bleomycin-induced Sweet's syndrome.

Anuja Yadav¹, Vishal Gaurav, Deepika Yadav

¹Department of Dermatology and Venereology, Maulana Azad Medical College, Delhi, India.

Indian Journal of Pharmacology

|August 22, 2025

Summary

This summary is machine-generated.

Acute febrile neutrophilic dermatosis, or Sweet's syndrome, is rarely caused by drugs. This report details the first known case of bleomycin-induced Sweet's syndrome, a rare dermatosis.

Keywords:

Bleomycin Sweet’ syndrome chemotherapy

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Area of Science:

Dermatology
Oncology
Pharmacology

Background:

Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition.
Drug-induced cases are uncommon, with trimethoprim-sulfamethoxazole being a previously reported cause.
Bleomycin is an antineoplastic agent used in cancer treatment.

Observation:

A patient developed symptoms consistent with Sweet's syndrome.
The patient had recently been treated with bleomycin.

Findings:

This case represents the first documented instance of bleomycin-induced Sweet's syndrome.
The findings suggest a potential adverse reaction to bleomycin therapy.

Implications:

Highlights the importance of considering bleomycin as a potential trigger for Sweet's syndrome.
May prompt further investigation into the relationship between bleomycin and neutrophilic dermatoses.
Informs clinical practice regarding differential diagnosis in patients on bleomycin treatment.