Uveitis in Psoriatic Arthritis: A Comprehensive Review

Psoriatic arthritis (PsA) belongs to the spectrum of spondyloarthritides, primarily affecting skin and joints. Apart from skin involvement, other extra-articular manifestations can coexist. Uveitis, although not very frequently encountered, is one of the most serious of them, necessitating prompt diagno- sis and proper treatment to prevent irreversible sight-threatening complications. Psoriatic arthritis related uveitis is usually unilateral, characterized by anterior segment inflammation, with the absence of redness or pain making it possible to miss the diagnosis. This review gives a comprehensive insight into the pathophysiology and clinical manifestations of PsA-related uveitis, along with an exposition of various epidemiologic features, as derived from relevant observational studies. Therapeutic approaches and available treatments are also reviewed. Although definitive recommendations on treatment seem rather challenging for PsA-related uveitis, tumor necrosis factor inhibitors appear to have the lead over other biologic therapies. A multi-disciplinary approach, tight screening, and disease activity control, as well as proper targeted therapy, remain pivotal.