2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer

Area of Science:

• Endocrinology
• Oncology
• Clinical Practice Guidelines

Background:

• Differentiated thyroid cancer (DTC) is a prevalent malignancy.
• The American Thyroid Association (ATA) guidelines for DTC management have been periodically updated since 1996.
• This update aims to provide contemporary guidance for adult DTC patient care.

Purpose of the Study:

• To present revised, evidence-based practice guidelines for the management of adult differentiated thyroid cancer.
• To emphasize the patient journey from diagnosis through long-term care.
• To incorporate recent scientific advances and stakeholder input.

Main Methods:

• Systematic literature reviews were conducted to inform recommendations.
• A modified Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used for evidence appraisal.
• Guidelines were developed by a multidisciplinary panel, including a patient advocate.

Main Results:

• Recommendations span initial diagnosis, staging, risk assessment, treatment, response assessment, monitoring, and subsequent therapies.
• Guidelines consider evidence strength, side effects, and patient-reported outcomes.
• Areas requiring further high-quality research are identified.

Conclusions:

• Revised guidelines support evidence-based clinical decision-making for differentiated thyroid cancer management.
• These recommendations reflect evolving scientific understanding and optimize patient care throughout the DTC journey.
• The update highlights critical needs for future research in DTC.