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Evolution of Hepatitis A-Related Acute Liver Failure in North America Over 22 years
Usamah Chaudhary1, Ahmad Anouti2, Jody A Rule3
1Department of Internal Medicine, UT Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Introduction:
Hepatitis A virus (HAV) is a rare cause of acute liver failure (ALF) that carries a relatively good prognosis for recovery. In recent years, overall numbers of HAV cases have declined, likely because of increased hepatitis A vaccination rates.
Methods And Results:
We reviewed the Acute Liver Failure Study Group registry for the number HAV-related ALF cases over 24 years.
Discussion:
Overall, the number of HAV ALF cases enrolled steeply declined. After 2010, when we began recording acute liver injury (ALI: International normalized ratio ≥ 2 but no encephalopathy), an apparent increase in ALI incidence was noted, despite a near absence of ALF cases.
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