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New Eczematous Eruption in Patients With Inflammatory Bowel Disease Who Stop Janus Kinase Inhibitors
Russell Yanofsky1, Benjamin D McDonald1,2, Newsha Nikzad2
1University of Chicago Medicine Inflammatory Bowel Disease Center, University of Chicago, Chicago, Illinois, USA.
Introduction:
Janus kinase inhibitors (JAKi) are small-molecule therapies used in inflammatory bowel disease (IBD). We describe 8 patients with IBD who developed an eczematous eruption, presumed atopic dermatitis (AD), after stopping JAKi therapy.
Methods:
This case series describes 8 patients with IBD who developed de novo AD after withdrawal of JAKi therapy.
Results:
Median time to AD onset was 7 days (interquartile range 2-12). Two cases with biopsy-confirmed AD resolved after reinitiation of JAKi therapy and adjunct AD treatments.
Discussion:
A subset of patients with IBD may have latent susceptibility to AD, unmasked by therapy cessation and potentially triggered by an immune rebound effect.
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