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Updated: Sep 10, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

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KIAA1429 Silencing ameliorates osteosarcoma progression through promoting ferroptosis via Nrf2/NQO1 axis

Cheng Xie1, Yihui Xiao1, Lubing Yang1

  • 1Department of Spine Surgery, The First Affiliated Hospital of Gannan Medical University, No. 128 Jingling Road, Ganzhou, 341099, Jiangxi, People's Republic of China.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|August 22, 2025
PubMed
Abstract

Insights

Silencing KIAA1429 promotes ferroptosis, a cell death process, in osteosarcoma (OS) cells. This finding offers a new therapeutic strategy for treating this common bone cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Death Research

Background:

  • Osteosarcoma (OS) is the most prevalent primary malignant bone tumor.
  • Ferroptosis, a regulated cell death pathway, presents novel therapeutic opportunities for OS.
  • The specific role of KIAA1429 in ferroptosis and its mechanisms in OS are not well understood.

Purpose of the Study:

  • To investigate the function of KIAA1429 in regulating ferroptosis in osteosarcoma.
  • To elucidate the underlying molecular mechanisms by which KIAA1429 influences ferroptosis in OS.
  • To assess the therapeutic potential of targeting KIAA1429 in OS treatment.

Main Methods:

  • KIAA1429 silencing effects on ferroptosis were assessed in OS cells and an OS mouse model.
  • Methylation analysis of Nrf2 and NQO1 transcripts was performed using SRAMP and MeRIP-qPCR.
  • The Nrf2/NQO1 signaling pathway was investigated following KIAA1429 knockdown using RTA-408.

Main Results:

  • KIAA1429 silencing enhanced erastin-induced ferroptosis and suppressed tumor growth in vivo.
  • KIAA1429 was found to directly regulate Nrf2 via m6A modification of its 3'UTR.
  • KIAA1429 depletion inhibited OS cell viability, migration, and invasion, while promoting apoptosis through the Nrf2/NQO1 pathway.

Conclusions:

  • KIAA1429 silencing promotes ferroptosis in osteosarcoma.
  • This action potentially delays OS progression by modulating the Nrf2/NQO1 signaling pathway.
  • Targeting KIAA1429 represents a promising therapeutic strategy for osteosarcoma.
Keywords:
FerroptosisKIAA1429Nrf2/NQO1Osteosarcoma

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