Research and development prospects of TRIM65
Nian-Hua Deng1, Jie-Hai Chen2, Zhen Tian1
1The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, 523326, Guangdong, People's Republic of China.
Journal of Cancer Research and Clinical Oncology
|August 22, 2025
Summary
This review summarizes the role of TRIM65, an E3 ubiquitin ligase, in cellular processes like inflammation and cancer. Understanding TRIM65 mechanisms may lead to new therapies for diseases.
Area of Science:
- Biochemistry
- Molecular Biology
- Cell Biology
Background:
- Ubiquitination is a key posttranslational modification regulating protein function.
- TRIM65, an E3 ubiquitin ligase, influences inflammation, immunity, proliferation, apoptosis, and cancer.
- Existing research highlights TRIM65's significant cellular roles.
Purpose of the Study:
- To compile and review existing research on TRIM65.
- To establish a foundation for future studies on TRIM65 mechanisms.
- To explore the therapeutic potential of targeting TRIM65.
Main Methods:
- Literature review and synthesis of current TRIM65 research.
- Analysis of TRIM65's role in various cellular pathways.
- Discussion of potential therapeutic strategies targeting TRIM65.
Main Results:
- TRIM65 regulates critical cellular processes including inflammation and tumor progression.
- Understanding TRIM65-substrate interactions is vital for disease insights.
- TRIM65 modulation offers therapeutic potential for inflammatory and cancerous diseases.
Conclusions:
- TRIM65 is a crucial regulator of fundamental cellular processes.
- Further research into TRIM65 mechanisms can illuminate disease pathways.
- Targeting TRIM65 presents novel therapeutic opportunities for cancer and inflammatory diseases.
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