Related Experiment Video

Updated: May 8, 2026

Combining Lipophilic dye, in situ Hybridization, Immunohistochemistry, and Histology
13:05

Combining Lipophilic dye, in situ Hybridization, Immunohistochemistry, and Histology

Published on: March 17, 2011

26.7K

The power of two: Combining imaging and sequencing as readouts for in vivo pooled genetic screens

Carlos Jiménez1, Nicola Crosetto2, Magda Bienko2

  • 1Human Technopole, Milan, Italy.

Molecular Cell
|August 22, 2025
PubMed

Abstract:

In a recent publication in Cell, Saunders et al.1 describe an important step forward for in vivo genetic screens, by enabling parallel tissue imaging and sequencing, boosting the discovery of gene-phenotype links that had previously gone unnoticed.

More Related Videos

Pooled CRISPR-Based Genetic Screens in Mammalian Cells
09:05

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

22.2K
Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.7K

Related Experiment Videos

Last Updated: May 8, 2026

Combining Lipophilic dye, in situ Hybridization, Immunohistochemistry, and Histology
13:05

Combining Lipophilic dye, in situ Hybridization, Immunohistochemistry, and Histology

Published on: March 17, 2011

26.7K
Pooled CRISPR-Based Genetic Screens in Mammalian Cells09:05

Pooled CRISPR-Based Genetic Screens in Mammalian Cells

Published on: September 4, 2019

22.2K
Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

3.7K

Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

Articles linked to this work by shared authors, journal, and citation graph.

Integrated Multi-Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Naive T cell-depleted hematopoietic stem cell transplantation to minimize immunosuppression after solid organ transplantation: case report.

Communications medicine·2026

Potato (Solanum tuberosum L., cv. Spunta) Peels Promote the Production of Broad Spectrum Antibacterial Chemicals by Bacillus velezensis B38.

Molecules (Basel, Switzerland)·2026

Multicentre, controlled, randomised and single-blind, adaptive phase IV protocol to evaluate effectiveness and cost-effectiveness of a pre-emptive genotyping strategy to optimise tacrolimus dosage in a pretransplant chronic kidney disease population cohort: iPHARMGx TRANSPGx nested clinical trial.

BMJ open·2026

Larval collectors network documents the spread of the invasive bivalve Pinctada radiata in the Mediterranean Sea.

Marine environmental research·2026

Validation of a Broad-Range Conventional RT-PCR Assay for Pestivirus Surveillance and Molecular Detection of BVDV-2a in Pigs in Costa Rica.

Viruses·2026

A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability.

Molecular cell·2026

PHYHD1-mediated translational control regulates renal cell carcinoma progression.

Molecular cell·2026

Oligo(uridine) tailing and exonucleolytic decay drive 40S ribosome degradation in response to stress.

Molecular cell·2026

40S ribosome remodeling triggers 18S rRNA U-tailing and DIS3L2-dependent decay.

Molecular cell·2026

Mechanistic insights into chromatin modulation by the "orphan" remodeler ATRX.

Molecular cell·2026

Ribosome remodeling drives translation adaptation during viral infection and cellular stress.

Molecular cell·2026

Immune-related molecular links between asthma and Alzheimer's disease identified by multi-omics, machine learning and single-cell analysis.

Frontiers in cell and developmental biology·2026

Network-based hierarchical heterogeneity analysis and applications to cancer omics data.

Science China. Mathematics·2026

Neural Differentiation and Apoptosis in Glioblastoma Driven by GQIcombi: Evidence from RNA-seq Analysis.

Current neuropharmacology·2026

Expression and Functional Characterization of NR1D2 in Gastric Cancer.

Omics : a journal of integrative biology·2026

Integrative Bioinformatics Identifies TTN as a Potential Diagnostic Marker for Rheumatoid Arthritis.

Current medicinal chemistry·2026

Flexible Integration of Structurally Diverse Spatial Multi-Omics With AgaeSMO.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us