Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

1.5K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.5K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Tumor Progression02:07

Tumor Progression

6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Development of the Lymphatic System01:15

Development of the Lymphatic System

1.1K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
1.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

72.4K
Overview
72.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanded antigen-specific donor regulatory T cells for GVHD prevention.

Blood·2026
Same author

Correction: Understanding Physician Referral for Chimeric Antigen Receptor T-Cell (CAR-T) Therapy.

Journal of cancer education : the official journal of the American Association for Cancer Education·2026
Same author

Exercise Prehabilitation for Older Adults Undergoing CAR-T: Feasibility, Acceptability, and Preliminary Outcomes.

Transplantation and cellular therapy·2026
Same author

Product-Intrinsic NF-κB-Driven Transcriptional Programs Connote Durability of CAR-T Response in Multiple Myeloma.

Blood·2026
Same author

Adiponectin preserves follicles through ADIPOR1/ADIPOR2-driven fatty acid metabolism.

Molecular metabolism·2026
Same author

The transcription factor LSD-one-like 2 binds to a novel identified cis-element LBE (GCCAAAAC) and regulates molecular response of Populus davidiana×P. bolleana to salt stress.

International journal of biological macromolecules·2026
Same journal

Vascular RhoJ Is an Effective and Selective Target for Tumor Angiogenesis and Vascular Disruption.

Cancer cell·2026
Same journal

Intratumoral B cells under stress.

Cancer cell·2026
Same journal

Chronic stress unleashes an intratumor phage-fibroblast-B cell circuit to promote tumor growth.

Cancer cell·2026
Same journal

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.

Cancer cell·2026
Same journal

OpenIO: An open framework for AI-native immunotherapy.

Cancer cell·2026
Same journal

From prediction to interpretation in computational pathology.

Cancer cell·2026
See all related articles

Related Experiment Video

Updated: Sep 10, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.2K

Lymphoma accelerates T cell and tissue aging.

Rebecca S Hesterberg1, Joshua T Davis2, Komal J Handoo1

  • 1Department of Tumor Microenvironment & Metastasis, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

Cancer Cell
|August 22, 2025
PubMed
Summary
This summary is machine-generated.

Cancer and aging significantly alter immune cells. While young T cells show lymphoma-induced aging, aged T cells resist these changes, revealing potential therapeutic targets for cancer-associated aging.

Keywords:
B cell lymphomaNK cellT cellagingferroptosis

More Related Videos

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.2K

Related Experiment Videos

Last Updated: Sep 10, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.2K
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

2.1K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.2K

Area of Science:

  • Immunology
  • Gerontology
  • Oncology

Background:

  • Aging and cancer profoundly impact immune cell function.
  • Investigating the interplay between aging and B cell lymphoma is crucial for understanding immune dysregulation.

Purpose of the Study:

  • To examine the combined effects of aging and B cell lymphoma on T cell alterations.
  • To identify molecular mechanisms underlying these changes and assess reversibility.

Main Methods:

  • Comparative analysis of T cells from young and aged mice with B cell lymphoma.
  • Analysis of T cells from young and aged B cell lymphoma patients.
  • Transcriptional, epigenetic, and phenotypic profiling of T cells.
  • Pathway analysis focusing on chromatin accessibility, iron homeostasis, and proteostasis.

Main Results:

  • B cell lymphoma induces aging-like changes in young T cells, but aged T cells are resistant.
  • Both aging and lymphoma increase iron pools and ferroptosis resistance in T cells.
  • Defects in proteostasis are observed in aged and lymphoma-experienced T cells.
  • Lymphoma accelerates aging in other tissues, indicated by elevated Cdkn2a and Tnfa expression.

Conclusions:

  • Lymphoma-induced T cell aging phenotypes differ between young and aged individuals.
  • Shared pathways involving iron homeostasis and proteostasis are implicated in aging and lymphoma.
  • Some cancer-associated aging phenotypes are reversible, suggesting therapeutic intervention possibilities.