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Updated: Sep 10, 2025
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Lymphoma accelerates T cell and tissue aging
Rebecca S Hesterberg1, Joshua T Davis2, Komal J Handoo1
1Department of Tumor Microenvironment & Metastasis, Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Cancer and aging significantly alter immune cells. While young T cells show lymphoma-induced aging, aged T cells resist these changes, revealing potential therapeutic targets for cancer-associated aging.
Area of Science:
- Immunology
- Gerontology
- Oncology
Background:
- Aging and cancer profoundly impact immune cell function.
- Investigating the interplay between aging and B cell lymphoma is crucial for understanding immune dysregulation.
Purpose of the Study:
- To examine the combined effects of aging and B cell lymphoma on T cell alterations.
- To identify molecular mechanisms underlying these changes and assess reversibility.
Main Methods:
- Comparative analysis of T cells from young and aged mice with B cell lymphoma.
- Analysis of T cells from young and aged B cell lymphoma patients.
- Transcriptional, epigenetic, and phenotypic profiling of T cells.
- Pathway analysis focusing on chromatin accessibility, iron homeostasis, and proteostasis.
Main Results:
- B cell lymphoma induces aging-like changes in young T cells, but aged T cells are resistant.
- Both aging and lymphoma increase iron pools and ferroptosis resistance in T cells.
- Defects in proteostasis are observed in aged and lymphoma-experienced T cells.
- Lymphoma accelerates aging in other tissues, indicated by elevated Cdkn2a and Tnfa expression.
Conclusions:
- Lymphoma-induced T cell aging phenotypes differ between young and aged individuals.
- Shared pathways involving iron homeostasis and proteostasis are implicated in aging and lymphoma.
- Some cancer-associated aging phenotypes are reversible, suggesting therapeutic intervention possibilities.
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