Association between triglyceride glucose-weight-adjusted waist index and stroke risk in the general population: A
Quanhong Chu1, Yaoyao Shen1, Shimin Liu1
1Department of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases) No, 266 Fenghe North Avenue, Honggutan District, Nanchang, Jiangxi 330038, China; Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College. No, 266 Fenghe North Avenue, Honggutan District, Nanchang, Jiangxi 330038, China.
Background:
Insulin resistance (IR) is closely associated with stroke risk. The triglyceride glucose-weight-adjusted waist index (TyG-WWI) is a novel biomarker for IR estimation. However, the relationship between the TyG-WWI index and stroke risk in the general population remains unexplored. This study aims to explore the potential relationship between the TyG-WWI index and stroke risk in the general population.
Methods:
A total of 22,615 participants from the 1999-2018 NHANES programme were included in this study. Multivariate logistic regression models, restricted cubic spline regression, subgroup analyses and sensitivity analysis were performed to explore the relationship between the TyG-WWI index and stroke risk in the general population.
Results:
Among the 22,615 participants included in the study, 812 participants were identified as stroke patients. After adjusting for multiple confounders, multivariate logistic regression analyses indicated that each SD (standard deviation) increase in the TyG-WWI index was associated with a 15 % increase in the risk of stroke (OR: 1.15, 95 % CI: 1.01-1.32). The further restricted cubic spline analysis demonstrated a positive linear relationship between the TyG-WWI index and stroke risk (p for non-linearity: 0.149). Subgroup analysis showed a more pronounced association between the TyG-WWI index and stroke risk among younger participants and those without coronary heart disease. Finally, sensitivity analysis consistently confirmed the robustness of the study findings.
Conclusions:
The findings indicate a positive linear relationship between the TyG-WWI index and stroke risk in the general population.
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