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Updated: Sep 10, 2025
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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
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Platelet Function: Acute versus Chronic Responses to Physical Exercise: A Review
Apostolos Z Skouras1, Andreas G Tsantes2,3, Panagiotis Koulouvaris1
1Sports Excellence, 1st Department of Orthopaedic Surgery, "Attikon" Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Seminars in Thrombosis and Hemostasis
|August 22, 2025
Summary
Regular exercise benefits platelet function and hemostatic balance. However, unaccustomed extreme exertion may increase thrombotic risk, especially in high-risk individuals.
Area of Science:
- Cardiovascular Physiology
- Exercise Science
- Hemostasis and Thrombosis
Background:
- Platelets are crucial for hemostasis and arterial thrombosis.
- Physical exercise significantly influences platelet function and reactivity.
- Evidence suggests exercise modulates platelet aggregation, degranulation, and coagulation.
Purpose of the Study:
- To review the association between platelet function and various exercise modalities.
- To compare the effects of different exercise types, intensities, and fitness levels on platelets.
- To identify methodological challenges in studying exercise and platelet function.
Main Methods:
- Literature review examining studies on exercise and platelet function.
- Comparison of aerobic, resistance, and high-intensity interval training effects.
- Analysis of factors influencing exercise-induced platelet responses, including intensity and individual variability.
Main Results:
- Acute exercise, especially intense bouts, can transiently increase platelet activity and hypercoagulability.
- Regular training generally reduces resting platelet reactivity and enhances endothelial nitric oxide (NO) bioavailability.
- Favorable adaptations may decrease with detraining, highlighting the dynamic nature of exercise effects.
Conclusions:
- Consistent, appropriately progressed exercise is generally beneficial for hemostatic balance.
- Extreme exertion without preparation poses risks, particularly for high-risk individuals.
- Standardized protocols and biomarker-guided trials are needed to optimize exercise for thrombotic risk reduction.
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