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Published on: August 17, 2022
Effect of high-flow nasal oxygen therapy on cardiac cycle efficiency in coronary artery disease patients undergoing
Fang Xie1, Mu Jin1, Tingting Ma1
1Department of Anesthesiology, Beijing An Zhen Hospital, Chaoyang-qu, Beijing, China.
Introduction:
Patients with coronary artery disease (CAD) have diminished tolerance for gastrointestinal endoscopy procedures (upper/lower) performed under deep sedation, resulting in increased incidence rates of hypotension and myocardial ischaemia among these patients. Avoiding hypoxemia caused by deep sedation and increased oxygen consumption caused by inadequate sedation is particularly important in these patients. Based on recent data indicating that high-flow nasal oxygen therapy (HFNO) is beneficial for preventing hypoxaemia in high-risk patients, this study investigated whether HFNO can improve myocardial oxygen supply during gastrointestinal endoscopy under deep sedation. Using cardiac cycle efficiency (CCE) data from MostCare to assess myocardial oxygen supply-demand balance in patients with CAD, we tested the hypothesis that compared with standard oxygen therapy (SOT), HFNO can improve CCE in patientswith CAD during gastrointestinal endoscopy under deep sedation.
Methods And Analysis:
This single-centre randomised controlled trial will compare the effects of HFNO and SOT among CAD patients during gastrointestinal endoscopy under deep sedation administered by anaesthesiologists. 90 patients will be randomly allocated in a 1:1 ratio to two parallel groups. The primary outcome will be the difference in CCE between the two groups during sedation. Secondary outcomes will include the incidence of hypotension; the occurrence of hypoxemia; brain natriuretic peptide, troponin I and lactate levels at 6-12 hours postoperation; frequency of patient agitation episodes; intraoperative adverse memory recall; need for mask ventilation or any airway intervention; duration of sedation; HFNO-related adverse events; and MostCare haemodynamic parameters other than the primary outcome.
Ethics And Dissemination:
This study has been approved by the Ethics Committee of Beijing Anzhen Hospital, Capital Medical University (KS2024066), and patients will be included after providing informed consent. The results will be submitted to a peer-reviewed journal for publication.
Trial Registration Number:
ChiCTR2400086887.
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