Iomeprol-induced acute generalised exanthematous pustulosis (AGEP)

Acute generalised exanthematous pustulosis (AGEP) is an uncommon but severe cutaneous adverse drug reaction characterised by the abrupt onset of numerous sterile, non-follicular pustules on erythematous and oedematous skin, often accompanied by fever and leucocytosis. Although medications are the primary aetiological factor, AGEP may also be precipitated by exposure to certain chemicals, dyes or infectious agents. Despite its low incidence, estimated at 1-5 cases per million each year, AGEP remains a clinically significant condition with potential for severe morbidity and, in rare cases, fatality.We report a case of AGEP in a woman in her 30s, triggered by exposure to the iodinated radiocontrast agent iomeprol. While AGEP induced by iodinated contrast media is rare, it represents an important diagnostic consideration, particularly in patients undergoing imaging studies. Early recognition, along with appropriate diagnostic strategies such as patch testing, is crucial for effective management and prevention of recurrence.