Related Experiment Video
Updated: Sep 10, 2025
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Treatment Patterns of Patients With Multiple Myeloma in a Real-World Setting in Spain. How are Triple-Class Exposed
Julia Llinares1, Sofía Toribio-Castelló1, Luis Fernando García1
1Pfizer SLU, Madrid, Spain.
Objective:
We aim to describe multiple myeloma (MM) characteristics and treatment patterns in Spain, focusing on triple-class exposed (TCE) population.
Methods:
In this non-interventional, cross-sectional, retrospective study, real-world treatment data between October 2022 and September 2023 were collected from Oncology Dynamics and Oncology Advantage datasets. The proportion of TCE patients was described by line of therapy (LOT).
Results:
In total, 1206 MM patients were analyzed. Of them, 717 patients were newly diagnosed MM and 489 were relapsed and refractory MM (RRMM) patients. In RRMM patients, treatment patterns were heterogeneous, mainly with lenalidomide- and pomalidomide-based regimens in the second and third/subsequent LOT, respectively. Among patients with ≥ 3 LOT, 82 different treatment sequences were identified. Currently, a total of 331 (27.4%) patients were TCE, with a notably increase by LOT: 15.9% receiving triple-class agents in the first, 56.9% in the second and 62.1% in the third/subsequent LOTs. To note, only a 7.13% of patients (n = 86) were TCE at the beginning of their current treatment.
Conclusions:
This study shows the increasingly incidence of TCE-MM patients, appearing from the first LOT. TCE treatment is challenging and identifying treatments with new mechanism of actions regardless of LOTs, will be key to optimize the management of this population.
More Related Videos
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Related Concept Videos
02:56Treatment Resistant Cancers
01:22Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...