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Updated: Sep 10, 2025
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Author Spotlight: Ex Vivo Protocol for Culturing Quiescent Muscle Stem Cells with Niche Components
Published on: June 2, 2023
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Metabolic symphony coordinates the muscle regeneration niche
Yang Lu1, Zhexu Chi2, Di Wang1
1Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, PR China; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 310058, PR China.
Trends in Molecular Medicine
|August 22, 2025
Summary
Muscle regeneration involves complex cell interactions and metabolic shifts. Understanding this metabolic niche is key to developing interventions for better muscle repair, especially in aging and disease.
Area of Science:
- Muscle regeneration biology
- Cellular metabolism
- Tissue repair and homeostasis
Background:
- The muscle regeneration niche includes muscle stem cells (MuSCs), immune cells, and stromal cells.
- Metabolic reprogramming is critical for cell function during muscle injury and repair.
- Disrupted metabolic homeostasis, due to aging or disease, impairs muscle regeneration.
Purpose of the Study:
- To provide a comprehensive overview of the metabolic profile within the muscle regeneration niche.
- To highlight potential metabolic interventions for enhancing muscle regeneration.
- To explore the role of cell-cell metabolic crosstalk and cross-organ regulation in muscle repair.
Main Methods:
- Review of recent scientific literature on muscle regeneration and cellular metabolism.
- Analysis of metabolic pathways and reprogramming in the context of muscle stem cell function.
- Examination of how aging and disease impact metabolic homeostasis in the muscle niche.
Main Results:
- Muscle regeneration relies on intricate metabolic activities within a niche of diverse cell types.
- Cell-cell metabolic crosstalk and cross-organ regulation significantly influence regeneration outcomes.
- Metabolic dysfunction in the niche is a key factor in age-related and disease-associated muscle impairment.
Conclusions:
- A thorough understanding of the muscle regeneration metabolic niche is essential for therapeutic development.
- Targeting metabolic reprogramming holds promise for improving regenerative capacity.
- Interventions aimed at restoring metabolic homeostasis can combat muscle dysfunction.
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