Related Experiment Video
Updated: Sep 10, 2025
Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
Early Postoperative Value of C-Reactive Protein: A Tool for Predicting or Excluding Complications After Elective
Michele Paterno1,2, Thibaud Bertrand1, Nicolas Golse1,3
1Department of Surgery, Centre Hepatobiliaire, Hôpital Paul Brousse, Villejuif, France.
Background:
The predictive value of C-reactive protein (CRP) for anticipating or ruling out complications after elective abdominal surgery has been extensively studied. However, its role following elective liver resection (LR) remains poorly explored. This study aimed to evaluate the performance of CRP levels after LR.
Methods:
The CRP values on postoperative day (POD) 1, 3 and 5 in a cohort of patients undergoing elective LR at a single tertiary center were retrospectively analyzed. Analyses were performed for laparoscopic and major LR subgroups.
Results:
A total of 448 LR (392 patients), including 134 laparoscopic LR and 169 major LR, were analyzed. Severe morbidity (Clavien-Dindo grade ≥ III) occurred in 56 cases (12.4%) with an overall 90-day mortality rate of 2% (n = 9). Peak CRP levels were observed on POD 3. On POD 3, CRP levels were lower in the laparoscopic subgroup compared to open LR and lower after major LR compared to limited LR. In the overall cohort, the predictive CRP value on POD 1, 2, 3 remained poor for detecting major complications or any complications, with all calculated area under the curve (AUCs) below 0.65. Among the 69 patients with a POD 3 CRP value < 100 mg/L, only 2 developed major complications.
Conclusion:
Unlike other abdominal procedures, CRP levels on POD 1, 3 and 5 after LR have insufficient predictive value for guiding postoperative management. The role of alternative biomarkers or early imaging strategies should be investigated.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:23Peripheral Artery Disease V: Postoperative Nursing Management
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:28Cardiomyopathy VII: Pre and Post Operative Nursing Management
01:29Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...