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Clinical Trials in Central Venous Access Devices: An Evidence and Gap Map
Mari Takashima1,2,3, Areum Hyun4, Tricia Kleidon1,2,5
1School of Nursing, Midwifery and Social Work, Faculty of Health and Behavioural Sciences, The University of Queensland, St Lucia, Queensland, Australia.
Journal of Advanced Nursing
|August 23, 2025
Summary
Central venous access device research heavily focuses on insertion and infection prevention. Gaps exist in device selection, removal, patient-reported outcomes, and cost-effectiveness, impacting nursing practice and patient care.
Area of Science:
- Medical Research
- Nursing Science
- Evidence Synthesis
Background:
- Central venous access devices (CVADs) are crucial in patient care.
- Evidence mapping of CVAD research is needed to identify practice gaps.
- A comprehensive review of CVAD literature from 2014-2024 is essential.
Purpose of the Study:
- To systematically map the research landscape of central venous access device (CVAD) interventions and outcomes from 2014 to 2024.
- To identify critical evidence gaps in CVAD research impacting nursing practice and patient outcomes.
- To analyze the full device lifecycle, from selection to removal.
Main Methods:
- Systematic review adhering to Campbell evidence and gap map guidance and PRISMA-ScR guidelines.
- Searched PubMed, CINAHL, Scopus, and Cochrane Central Register of Controlled Trials, with hand-searching.
- Mapped 710 studies published between 2014-2024, categorizing by design, population, setting, device, intervention, and outcomes.
Main Results:
- The majority of studies (n=710) focused on catheter insertion and infection prevention.
- Research was concentrated in high-income countries, on adults, and in hospital inpatient settings.
- Device selection and removal were understudied, as were patient-reported outcomes and cost-effectiveness.
Conclusions:
- Current central venous access device research predominantly addresses insertion and infection prevention.
- Significant gaps exist in research on device selection, removal, patient-reported outcomes, and cost.
- Future research must target these under-supported areas to enhance evidence-based nursing care.
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