Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

2.5K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.5K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.9K
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

256
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
256
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

491
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
491
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

2.4K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
2.4K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

2.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple endocrine neoplasia type 5: emerging evidence and clinical perspectives.

Endocrine-related cancer·2026
Same author

TGFβ signaling regulates the response of the skeleton to phosphate.

bioRxiv : the preprint server for biology·2026
Same author

Comment on "Pre-Operative Vitamin D Supplementation to Reduce Hypocalcemia Following Total Thyroidectomy: Systematic Review and Meta-Analysis of Randomized Clinical Trials".

Head & neck·2025
Same author

Health-related quality of life in a cohort of 1070 patients with hypoparathyroidism.

European journal of endocrinology·2025
Same author

Response to Letter to the Editor From Hasebe and Su: "Higher Risk of Cardiovascular Diseases in Patients With Chronic Hypoparathyroidism in Sweden".

The Journal of clinical endocrinology and metabolism·2025
Same author

Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation.

Nature communications·2025

Related Experiment Video

Updated: Sep 10, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.0K

Advances in Parathyroid Hormone-based medicines.

Anne-Laure Bonnet1,2, Lizaveta Aboishava3, Michael Mannstadt1

  • 1Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|August 23, 2025
PubMed
Summary

Parathyroid hormone (PTH) therapies, including analogs like teriparatide, are advancing bone health treatments. Intermittent administration favors bone formation, offering new options for osteoporosis and hypoparathyroidism.

Keywords:
PTH1Rfracture healinghypoparathyroidismosteoporosisparathyroid hormonesmall molecule GPCR agonists

More Related Videos

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

14.7K
Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification
08:07

Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification

Published on: August 1, 2025

697

Related Experiment Videos

Last Updated: Sep 10, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.0K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

14.7K
Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification
08:07

Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification

Published on: August 1, 2025

697

Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Parathyroid hormone (PTH) regulates calcium and phosphate homeostasis, impacting bone and kidney.
  • PTH influences bone remodeling by stimulating osteoblasts and osteocytes, balancing formation and resorption.
  • Dysregulation of PTH causes disorders like hyper- and hypoparathyroidism.

Purpose of the Study:

  • To review molecular mechanisms of PTH-based medicines.
  • To discuss clinical applications and advances in PTH analog therapies.
  • To explore potential of next-generation PTH analogs for skeletal and metabolic disorders.

Main Methods:

  • Review of scientific literature on PTH and its analogs.
  • Analysis of clinical trial data for approved PTH-based drugs.
  • Discussion of emerging research in PTH analog development.

Main Results:

  • Intermittent PTH administration favors bone formation, beneficial for osteoporosis treatment.
  • PTH analogs like teriparatide and abaloparatide show efficacy in stimulating bone formation.
  • Long-acting PTH analogs offer alternatives for hypoparathyroidism treatment.

Conclusions:

  • PTH analogs have significant therapeutic potential beyond osteoporosis, including fracture healing and oral bone repair.
  • Optimizing PTH analog administration patterns is key to maximizing therapeutic benefits.
  • Ongoing research aims to develop improved PTH analogs for various skeletal and metabolic conditions.