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Ultrastructure of the developing tree shrew lateral geniculate nucleus.

J K Brunso-Bechtold, V A Casagrande

|December 1, 1985

Summary

Ultrastructural development of the lateral geniculate nucleus (LGN) begins before cell layer formation. Increased growth cones in interlaminar spaces may correlate with LGN cell layer development in tree shrews.

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Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

The lateral geniculate nucleus (LGN) is a crucial relay center for visual information in the brain.
Understanding the developmental processes of the LGN, including cell layer formation and synaptogenesis, is essential for comprehending visual system development.

Purpose of the Study:

To investigate the ultrastructural development of the LGN in postnatal tree shrews.
To determine the correlation between specific ultrastructural features and the development of LGN cell layers.

Main Methods:

Examination of the ultrastructural development of the lateral geniculate nucleus (LGN) in postnatal tree shrews at birth (P0), postnatal day 8 (P8), and postnatal day 15 (P15).
Analysis of synaptogenesis, synaptic profile maturity, and growth cone distribution using electron microscopy.

Main Results:

Synaptogenesis begins at birth (P0), preceding the discernible development of LGN cell layers.
At P8, when laminar borders are visible, most synaptic profiles are immature; mature profiles and adult-like complex synaptic arrangements appear later (P15 onwards).
Growth cones are present at all observed ages, with higher prevalence at birth and potentially increased concentration in interlaminar spaces at P8 and P15.

Conclusions:

LGN cell layer formation is not correlated with the onset of synaptogenesis.
The development of LGN cell layers may be associated with an increase in growth cones within the interlaminar spaces.

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