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Postsurgical lateral canthal web correction using vertical Z-plasty combined with 5-fluorouracil (5-FU) injections
Ayşe Dolar Bilge1, Bülent Yazıcı2
1Dr. Ayşe Dolar Bilge Private Clinic, Caddebostan Mahallesi, Bağdat Caddesi, Şimşek Sokak No: 2/8, Kadıköy, Istanbul, Turkey. draysedolar@gmail.com.
International Ophthalmology
|August 23, 2025
Summary
Vertical Z-plasty with 5-fluorouracil (5-FU) injections effectively reconstructs lateral canthal webbing after surgery. This technique shows significant improvement and no recurrence, offering a valuable solution for complex cases.
Area of Science:
- Ophthalmology
- Plastic Surgery
- Reconstructive Surgery
Background:
- Post-surgical lateral canthal webbing presents a reconstructive challenge.
- Previous surgeries can lead to significant scarring and vertical skin contraction, complicating treatment.
Purpose of the Study:
- To evaluate the surgical outcomes of lateral canthus reconstruction using vertical Z-plasty combined with canthoplasty and 5-fluorouracil (5-FU) injections.
- To assess the efficacy of this combined technique in correcting post-surgical lateral canthal webbing.
Main Methods:
- Retrospective review of 11 patients (17 eyelids) undergoing lateral canthal reconstruction.
- Surgical technique involved vertical Z-plasty, canthopexy/canthoplasty, and 5-FU injections.
- Follow-up period averaged 14 months (range 5-23 months).
Main Results:
- No intraoperative complications were reported.
- All cases demonstrated significant improvement in lateral canthal webbing.
- No recurrence of webbing was observed during the follow-up period.
Conclusions:
- Vertical Z-plasty combined with 5-FU injections is an effective method for correcting lateral canthal webbing with minimal scarring.
- This technique is particularly advantageous for patients with a history of multiple surgeries, significant scarring, or vertical skin contraction.
- The technique can be successfully combined with a periosteal flap for concurrent lower eyelid horizontal shortening correction.

