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Obesity01:24

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Related Experiment Video

Updated: Sep 10, 2025

Isolation of Preadipocytes from Broiler Chick Embryos
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Does obesity affect embryo development and quality? A retrospective analysis.

G Younes1, N Kugelman1, I Blais2

  • 1Obsetrics and Gynaecology Department IVF Unit, Lady Davis Carmel Medical Centre, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Reproductive Biomedicine Online
|August 23, 2025
PubMed
Summary
This summary is machine-generated.

Maternal body mass index (BMI) does not significantly affect embryo development or quality in assisted reproductive technology cycles. This finding suggests that varying maternal weight does not impact key embryo morphokinetic parameters or overall embryo quality.

Keywords:
BMIMorphokinetic parametersObesityOverweightTime lapse

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Area of Science:

  • Reproductive Endocrinology
  • Embryology
  • In Vitro Fertilization (IVF)

Background:

  • Maternal body mass index (BMI) is a critical factor in reproductive health.
  • Understanding the impact of BMI on embryo development is crucial for optimizing IVF outcomes.

Purpose of the Study:

  • To investigate the association between maternal BMI and embryo morphokinetic parameters.
  • To evaluate the effect of different BMI categories on embryo quality and developmental potential.

Main Methods:

  • A retrospective analysis of 617 gonadotrophin-releasing hormone (GnRH) antagonist intracytoplasmic sperm injection (ICSI) cycles.
  • Comparison of embryo morphokinetics and quality across four BMI groups (<18.5, 18.5-24.9, 25-29.9, ≥30 kg/m²).
  • Assessment of key parameters including time to pronucleus appearance, cleavage timings, and blastocyst formation rates.

Main Results:

  • No significant differences were observed in oocyte yield, fertilization rates, or embryo creation rates across BMI groups.
  • Embryo morphokinetic parameters, including time to pronucleus appearance and cleavage timings, showed no significant variations between BMI groups.
  • Top-quality embryo rates at cleavage and blastocyst stages were comparable across all maternal BMI categories.

Conclusions:

  • Maternal BMI, even in extreme ranges, does not appear to significantly influence embryo morphokinetic parameters or quality.
  • Time-lapse monitoring data suggest that variations in maternal weight do not adversely affect early embryo development in ICSI cycles.
  • These findings indicate that BMI may not be a primary determinant of embryo developmental potential in the context of assisted reproduction.