Breaking new ground in CAD genetics: MCP-1 and CCR2 polymorphisms unveil pathways to personalized risk assessment
Foddha Hajer1, Saoud Hana2, Bouzidi Nadia1
1Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy, University of Monastir, Tunisia.
Background/Objectives:
Chemokines and their receptors are key mediators of inflammation and immune cell migration in atherosclerosis and coronary artery disease (CAD). This study examines the association of MCP-1-2518A/G (rs1024611), MCP-1-362G/C (rs2857656), and CCR2-V64I (rs1799864) polymorphisms with CAD susceptibility and severity in a Tunisian population.
Methods:
A total of 302 participants were included: 200 CAD patients and 102 healthy controls matched by age and sex. CAD was confirmed by coronary angiography, and severity assessed via the Gensini score. Genotyping was performed using PCR and RFLP analysis.
Results:
The MCP-1-2518G allele was significantly associated with increased CAD risk (p = 0.02; OR = 1.49 (1.09-2.48)), with stronger effects under the dominant model and after adjustment for confounders. This association was more pronounced in patients with myocardial infarction, obesity, and dyslipidemia. In contrast, the CCR2-V64I variant was associated with reduced CAD severity (p = 0.011; RD = 2.48 (2.01 to -2.95)), particularly in individuals without smoking habit, obesity, or dyslipidemia.
Conclusion:
MCP-1-2518A/G and CCR2-V64I polymorphisms may serve as genetic markers for CAD susceptibility and severity, offering potential for improved risk stratification and personalized therapeutic approaches.
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