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Unravelling the complex interplay between zinc, iron and their synergistic effect on LCPUFA metabolism in

Vaishnavi Mudgal1, Juhi Nema1, Sadhana Joshi1

  • 1Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India.

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|August 23, 2025
PubMed

Insights

Zinc and iron deficiency during pregnancy are linked to preeclampsia. These micronutrients are crucial for long-chain polyunsaturated fatty acids (LCPUFAs) synthesis, impacting pregnancy outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Biochemistry

Background:

  • Preeclampsia is a significant cause of maternal mortality and morbidity.
  • Long-chain polyunsaturated fatty acids (LCPUFAs) are vital for placental and fetal development.
  • Zinc and iron are essential micronutrients for pregnancy, and their deficiencies are linked to preeclampsia.

Purpose of the Study:

  • To review the role of zinc, iron, and LCPUFAs in preeclampsia.
  • To elucidate the synergistic mechanisms of zinc and iron in LCPUFA biosynthesis during preeclampsia.

Main Methods:

  • Literature review of studies on zinc, iron, LCPUFAs, and preeclampsia.
  • Analysis of the biochemical pathways involving zinc and iron as cofactors for desaturase enzymes.

Main Results:

  • Zinc and iron deficiencies are common in pregnancy and often coexist.
  • Zinc and iron influence each other's bioavailability and absorption.
  • These micronutrients are critical for the biosynthesis of LCPUFAs, essential for fetal development.

Conclusions:

  • Zinc and iron play a synergistic role in LCPUFA biosynthesis.
  • Understanding these interactions may offer insights into managing preeclampsia.
  • Micronutrient status, particularly zinc and iron, is critical in preeclampsia pathophysiology.

Keywords:
DesaturaseIronLCPUFAPreeclampsiaZinc

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