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Inflammatory cell death and leukemia treatment.

Saqib Ishaq1, Sajida Afzal2, Shabir Ahmad Usmani3

  • 1Guangdong Provincial Key Laboratory of System Biology and Synthetic Biology for Urogenital Tumors, School of Basic Medicine, Shenzhen University Medical School, Shenzhen University (SZU), Guangdong, Guangdong 518060, China; Department of Computer Sciences and Bioinformatics, Khushal Khan Khattak University, Karak, Karak 27200, Pakistan.

Critical Reviews in Oncology/Hematology
|August 23, 2025
PubMed
Summary

Inflammatory cell death pathways like pyroptosis, necroptosis, and ferroptosis are crucial in regulating leukemia development and resistance. Understanding these mechanisms offers new therapeutic strategies for blood cancers.

Keywords:
Cancer therapy resistanceFerroptosisImmunological responseInflammatory cell deathNecroptosisProgrammed cell deathPyroptosis

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Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Inflammatory cell death is vital for immune surveillance and tissue homeostasis.
  • Leukemia arises from aberrant hematopoietic stem and progenitor cells, with diverse subtypes.
  • Mechanisms of inflammatory cell death, including pyroptosis, necroptosis, and ferroptosis, influence leukemia progression and treatment.

Purpose of the Study:

  • To review therapeutic strategies for leukemia treatment focusing on inflammatory cell death.
  • To examine combination treatments, immunological response modifications, and personalized therapeutic approaches.

Main Methods:

  • Review of scientific literature on inflammatory cell death mechanisms in leukemia.
  • Analysis of pyroptosis, necroptosis, and ferroptosis pathways in the context of leukemia.
  • Evaluation of current and emerging therapeutic strategies targeting these pathways.

Main Results:

  • Pyroptosis, regulated by caspase activation, can suppress or promote leukemia.
  • Necroptosis, involving RIPK1 and RIPK3, offers an alternative death pathway for apoptosis-resistant leukemia cells.
  • Ferroptosis, an iron-dependent process, presents a novel strategy for treating therapy-resistant leukemia.

Conclusions:

  • Targeting inflammatory cell death pathways holds significant promise for advancing leukemia treatment.
  • Combination therapies and personalized approaches modulating immune responses are key to overcoming treatment resistance.
  • Further research into molecular pathway controls will drive the development of innovative therapeutic methods for blood cancers.