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Related Experiment Video

Updated: Sep 10, 2025

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Retinal curvature in myopia: correlation with ocular physiological parameters.

Siyu Yang¹, Ruibing Sun¹, Nan Xu¹

¹Department of Ophthalmology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, China.

Photodiagnosis and Photodynamic Therapy

|August 23, 2025

Summary

Retinal curvature (RC) decreases with myopia severity, showing significant negative correlation with axial length (AL) and positive correlations with refractive error and choroidal thickness. This indicates RC quantifies myopic changes.

Keywords:

Myopia OCTA Retinal curvature Ultra-wide-field

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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

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Published on: December 1, 2023

Area of Science:

Ophthalmology
Medical Imaging
Retinal Imaging

Background:

Myopia is a growing global health concern.
Understanding the structural changes in myopic eyes is crucial for management.
Retinal curvature (RC) is a geometric parameter potentially affected by myopia.

Purpose of the Study:

To investigate the correlation between retinal curvature (RC) and ocular physiological parameters in myopic eyes.
To assess how RC changes with varying degrees of myopia.
To explore the relationship between RC and choroidal vascularity.

Main Methods:

Retrospective analysis of clinical data from 332 patients (447 myopic eyes).
Classification into low, moderate, and high myopia based on spherical equivalent (SE) and axial length (AL).
Acquisition of ultra-widefield swept-source optical coherence tomography (UWF-SS-OCT) scans to create 3D retinal models and derive RC.
Quantification of retinal vessel density (RVD), subfoveal choroidal thickness (SFCT), and choroidal parameters using angiography.

Main Results:

Retinal curvature (RC) decreased significantly with increasing myopia severity.
RC showed a negative correlation with axial length (AL) and positive correlations with spherical equivalent (SE) and subfoveal choroidal thickness (SFCT).
In the macular and optic disc regions, RC positively correlated with choroidal vascular parameters, including choroidal vessel index (CVI), choroidal stromal volume per unit area (CSV/a), and choroidal vascular volume per unit area (CVV/a).

Conclusions:

Retinal curvature (RC) effectively quantifies retinal shape and morphological alterations in myopia.
High myopia is associated with significantly reduced RC.
RC is correlated with axial length, refractive error, choroidal thickness, and choroidal vascular parameters, highlighting its role in myopic eye changes.