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Updated: Sep 10, 2025

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Revolutionizing Mechanical Ventilation: Latest Advances and Practical Applications of Airway Pressure Release
Kelsey Hoidal1, Benjamin Cordy1, Alberto Rameriz1
1Division of Trauma, Acute Care Surgery, and Surgical Critical Care, Banner University Medical Center Phoenix/The University of Arizona College of Medicine Phoenix.
Abstract:
Airway pressure release ventilation (APRV) was historically used only to treat severe acute respiratory distress syndrome. However, because APRV optimizes alveolar recruitment and oxygenation while minimizing ventilator-induced lung injury, practice trends have shifted. Early initiation of APRV is now considered for lung protection rather than late use as salvage therapy. This mode limits ventilatory associated lung injury, decreases sedation requirements, and optimizes hemodynamic profiles. It has transitioned from a rescue therapy to a mode of lung protective ventilation. This article explains the foundation of APRV showcases the benefits of early implementation, and provides a practical blueprint for the bedside clinician.
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