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Updated: Sep 10, 2025

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
09:00

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease

Published on: October 31, 2012

16.0K

DecodingAcute GVHD: The role of serum biomarkers and imaging in diagnosis and management

Rohit Singh1, Happy Agarwal1, Ryan Bynum1

  • 1Stephenson Cancer Center, Department of Surgery, University of Oklahoma, Oklahoma City, OK 73104, USA.

Blood Reviews
|August 23, 2025
PubMed

Insights

Graft-versus-host disease (GVHD) remains a significant HCT complication. This review explores diagnostic biomarkers and imaging to improve early GVHD identification, severity prediction, and prognosis.

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Graft-versus-host disease (GVHD) is a primary obstacle to successful hematopoietic stem cell transplantation (HCT).
  • Despite therapeutic advancements, GVHD remains a leading cause of mortality post-HCT.
  • Current diagnostic methods for GVHD lack sufficient accuracy and timeliness, hindering effective early intervention.

Purpose of the Study:

  • To review current diagnostic serum biomarkers for predicting GVHD onset, severity, and prognosis.
  • To discuss advancements in imaging techniques for GVHD assessment.
  • To highlight the differential diagnosis of GVHD from other conditions.

Main Methods:

  • Literature review of diagnostic serum biomarkers for GVHD.
  • Analysis of imaging advancements in GVHD detection and monitoring.
  • Exploration of differential diagnostic criteria for GVHD.

Main Results:

  • Existing diagnostic tools for GVHD present challenges in accuracy and early detection.
  • Emerging serum biomarkers and imaging technologies show promise for improved GVHD prediction.
  • Distinguishing GVHD from other pathologies remains a clinical challenge.

Conclusions:

  • There is a critical need for validated biomarkers and advanced imaging to enhance early GVHD diagnosis.
  • Improved diagnostic strategies are essential for timely treatment and better HCT outcomes.
  • Further research is required to establish reliable markers for GVHD management.

Keywords:
BiomarkerDiagnosisGraft versus host diseaseImagingPathophysiology

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