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RARE-seq: an inflection point in cfRNA liquid biopsy
Jonathan C M Wan1, Ahmed Eldarwi2, Luis A Diaz3
1The Francis Crick Institute, 1 Midland Road, London, UK; University College London Hospital, Euston Road, London, UK.
Trends in Pharmacological Sciences
|August 23, 2025
Abstract:
Historically, the clinical application of cell-free RNA (cfRNA) liquid biopsies has been limited by background noise. In a recent study, Nesselbush et al. developed a method for denoising cfRNA analysis, resulting in RARE-seq, a versatile liquid biopsy platform that enables transcriptomic profiling, and cancer detection and monitoring, unlocking the potential of this exciting analyte.

