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Updated: Sep 10, 2025

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Published on: March 10, 2023
Roles of lactylation in lipid metabolism and related diseases
Bing Zhao1, Zhuoqing Lan2, Caixia Li3
1Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Abstract:
Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction. Recent studies have identified lactylation as a novel post-translational modification crucial for maintaining cellular and tissue equilibrium. Research has shown that lactylation regulates the turnover of proteins and lipids integral to lipid metabolism. However, comprehensive reviews addressing the complex relationship between lactylation and lipid metabolism are lacking. In this review, we summarize current findings regarding the influence of lactylation on lipid metabolism and the regulatory mechanisms. Further exploration of the intricate mechanisms underlying the role of lactylation in lipid metabolism, alongside the development of lactylation-targeted therapies, could provide innovative approaches to manage diseases linked to dysregulated lipid metabolism.
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