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Updated: Sep 10, 2025

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson's disease
Xingyue Chen1, Guoxin Zhang1, Miao Liu1
1Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Abstract:
Exercise offers neuroprotective benefits in Parkinson's disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, links exercise to neuronal health by regulating mitochondria and mitigating oxidative stress. Notably, irisin may serve as a therapeutic target for patients unable to exercise. Thus, exercise is a promising non-pharmacological intervention warranting further research for novel PD therapies.
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