Application of a proven treatment planning system for accelerator-based boron neutron capture therapy

This study introduces NeuMANTA (Multifunctional Arithmetic for Neutron Transportation Analysis), a dedicated treatment planning system (TPS) developed for accelerator-based boron neutron capture therapy (AB-BNCT). NeuMANTA integrates Monte Carlo-based dose calculation with modular workflow management to enable full-cycle support from imaging to post-treatment verification. Powered by the BNCT-specific COMPASS (COMpact PArticle Simulation System) engine, the system achieves dosimetric accuracy comparable to MCNP while reducing computation time by 2.8-fold. NeuMANTA supports heterogeneous boron distribution modeling, automated multi-scenario dose calculations based on measured blood boron concentrations, and polynomial dose-rate response fitting. It also enables seamless data exchange with external systems including patient positioning, boron measuring, and beam control via a dedicated radiotherapy data management system (RDMS). A clinical demonstration using the NeuPex platform in China's first investigator-initiated AB-BNCT trial validated the system's feasibility, accuracy, and clinical interoperability. These results highlight NeuMANTA's potential as a standardized platform for precision BNCT, offering reliable dose planning, adaptive delivery, and robust system integration.