Related Experiment Video
Updated: Sep 10, 2025
09:52
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
24.5K
The association between clock gene polymorphisms and type 2 diabetes: A systematic review and meta-analysis
Divya Joshi1, Marie Pigeyre2, Muhammad Usman Ali1
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Diabetes & Metabolic Syndrome
|August 24, 2025
Summary
Circadian clock gene variations, like CRY2 and MTNR1B, are linked to type 2 diabetes risk and glycemic control. Lifestyle factors can modify these genetic associations, suggesting potential for circadian-based interventions.
Area of Science:
- Genetics
- Endocrinology
- Chronobiology
Background:
- Circadian rhythm disruption is a potential risk factor for type 2 diabetes.
- Understanding the genetic basis of circadian function is crucial for metabolic health.
Purpose of the Study:
- To systematically review and meta-analyze the association between clock gene polymorphisms and glycemic parameters, including type 2 diabetes risk.
- To investigate the influence of environmental factors on these genetic associations.
Main Methods:
- Searched Embase, Medline, and Web of Science databases up to August 20, 2024.
- Included empirical studies on core and non-core clock gene polymorphisms related to glycemic control and type 2 diabetes.
- Employed a multi-level meta-analytical approach to determine pooled effects.
Main Results:
- 37 studies with 535,063 participants were analyzed.
- CRY2 polymorphisms correlated with higher fasting glucose and impaired glucose tolerance.
- MTNR1B polymorphisms increased type 2 diabetes risk, while CLOCK and PER3 showed protective associations.
- PER3 was linked to lower fasting insulin and insulin resistance.
- Gene variant effects were modified by diet, alcohol, physical activity, sleep, and daylight exposure.
Conclusions:
- Specific circadian gene polymorphisms (CRY2, MTNR1B, CLOCK, PER3) are associated with glycemic parameters and type 2 diabetes.
- Lifestyle and environmental factors significantly influence these genetic associations.
- Targeting circadian alignment may offer a novel strategy for modifying type 2 diabetes risk, warranting further investigation.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
01:20Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
01:11Genome-wide Association Studies-GWAS
14.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.1K
02:19Circadian Rhythms and Gene Regulation
4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
01:22Diabetes Mellitus: Overview and Type I Subtype
3.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.2K
01:15Diabetes: Symptoms, Diagnosis, and Complications
687
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
687