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Updated: Sep 10, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
"It's the future, come on!": a think aloud study exploring clinicians' use of knowledge-based AI decision support
Adele Hill1, Dylan Morrissey1, William Marsh1
1Queen Mary University of London, Bancroft Road, London E1 4NS, United Kingdom.
This study explored clinicians' experiences with AI clinical decision support (CDS) for low back pain. Findings reveal that user experience, workflow integration, and patient navigation are key to successful AI CDS implementation in healthcare.
Area of Science:
- Healthcare technology
- Clinical decision support systems
- Artificial intelligence in medicine
Background:
- AI-based clinical decision support (CDS) is proposed to address healthcare capacity challenges.
- A significant implementation gap exists for AI CDS.
- Existing research often relies on abstract definitions or general participant understanding of AI, lacking specific context.
Purpose of the Study:
- To address the research gap by examining the practical experience of AI CDS.
- To explore barriers and enablers of AI CDS implementation through direct user experience.
- To provide insights into the practical application of AI CDS before widespread adoption.
Main Methods:
- Phenomenological perspective with think-aloud protocol and cognitive interviews.
- Recruited 14 participants (5 doctors, 9 physiotherapists).
- Participants used a prototype AI CDS for assessing serious pathology in low back pain patients; analysis used grounded theory.
Main Results:
- Three themes emerged: Attitudes, Workflow, and Patient Navigation.
- Clinicians identified barriers and enablers within their work context, noting potential for decision support.
- Workflow integration, design, prompts, and clinical reasoning were crucial; timesaving features and organizational support were facilitators.
Conclusions:
- Directly exploring clinicians' experiences offers valuable insights into practical AI CDS application.
- Participants remained solution-focused, regardless of initial attitudes towards AI.
- The study highlighted how AI CDS can influence clinical judgment and patient journey navigation.
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