Related Experiment Video
Updated: May 5, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
Electro-responsive paper patch for enhanced transdermal methotrexate delivery in psoriasis treatment
Elham Momtaz1, Masoud A Mehrgardi1
1Department of Chemistry, University of Isfahan 81746-73441 Isfahan, Iran.
Abstract:
Transdermal delivery of high-molecular-weight drugs like methotrexate (MTX) is significantly hindered in psoriatic skin. To overcome this barrier, we developed a wearable iontophoretic patch based on a polypyrrole-coated paper substrate for enhanced MTX loading and controlled release. Applying -1.2 V enabled efficient MTX release and permeation (20.8 ± 0.4 μg/cm2 over 2 h) while minimizing passive leakage. In an imiquimod (IMQ)-induced psoriasis mouse model, the patch significantly alleviated symptoms and demonstrated low systemic toxicity. Histological analysis confirmed both therapeutic efficacy and biocompatibility. This innovative paper-based iontophoretic platform offers a promising strategy for precise, patient-friendly management of psoriasis and other dermatological disorders.
Related Concept Videos
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Therapeutic Drug Monitoring: Affecting Factors
Modified-Release Drug Delivery Systems: Stimuli-Activated
Transdermal Drug Delivery Systems

