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Menopause is not associated with asthma or severe asthma
Si Li1, Patricia Silveyra2, Bo Hu3
1Division of Pulmonary Medicine, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Ariz.
The Journal of Allergy and Clinical Immunology. in Practice
|August 24, 2025
Summary
Menopause effects on asthma are unclear due to confounding factors like age and hormone use. Further research into aging, inflammation, and hormone interactions is crucial for personalized asthma management.
Area of Science:
- Reproductive Health
- Pulmonary Medicine
- Endocrinology
Background:
- Asthma prevalence and severity can change throughout a woman's life.
- Menopause is a significant physiological transition associated with hormonal shifts.
- The direct impact of menopause on asthma control remains incompletely understood.
Purpose of the Study:
- To investigate the relationship between menopause and asthma outcomes.
- To identify factors that may confound the association between menopause and asthma.
- To explore the role of aging, inflammation, and hormone therapy in asthma during midlife.
Main Methods:
- Retrospective analysis of patient data.
- Statistical modeling to adjust for confounding variables.
- Comparison of asthma control metrics between pre- and post-menopausal women.
Main Results:
- The observed effects of menopause on asthma are influenced by age, obesity, and the use of female sex hormones.
- Specific hormonal changes during menopause may differentially impact asthma phenotypes.
- Confounding factors significantly alter the apparent relationship between menopause and asthma severity.
Conclusions:
- The influence of menopause on asthma is complex and multifactorial.
- Age, obesity, and hormone replacement therapy are significant confounders.
- Personalized asthma care strategies require a deeper understanding of aging, inflammation, and hormone interactions in women.
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