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Association between C-reactive protein-triglyceride glucose index and Future cardiovascular disease risk in a

Zhihui Lu1, Long Li1, Xiaolin Wang2

  • 1Department of Cardiology, The Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, China.

Scientific Reports
|August 24, 2025
PubMed

Insights

The C-reactive protein-triglyceride-glucose (CTI) index is linked to increased cardiovascular disease (CVD) risk in early stages of Cardiovascular-Kidney-Metabolic (CKM) syndrome. Higher CTI levels indicate a greater risk, suggesting its use for risk stratification.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Biomarkers

Background:

  • Cardiovascular-Kidney-Metabolic (CKM) syndrome highlights links between metabolic, renal, and cardiovascular diseases.
  • The C-reactive protein-triglyceride-glucose (CTI) index is a proposed biomarker for insulin resistance and inflammation.

Purpose of the Study:

  • To investigate the association between the CTI index and cardiovascular disease (CVD) risk in individuals with CKM syndrome stages 0-3.
  • To determine if CTI can serve as a practical tool for CVD risk stratification in this population.

Main Methods:

  • Prospective cohort study using data from the China Health and Retirement Longitudinal Study (CHARLS) with a 10-year follow-up.
  • Exposure: CTI calculated from triglyceride, fasting blood glucose, and C-reactive protein.
  • Analysis: Cox proportional hazards regression and restricted cubic spline (RCS) analysis.

Main Results:

  • An elevated CTI was significantly associated with a higher risk of developing CVD.
  • Each one-unit increase in CTI correlated with a 16% increase in CVD risk (HR=1.16, 95% CI: 1.06-1.27).
  • The highest CTI group showed a 42% greater CVD risk compared to the lowest group (HR=1.42, 95% CI: 1.20-1.68).
  • RCS analysis revealed a nonlinear association between CTI and CVD risk (overall P<0.001, nonlinearity P=0.01).

Conclusions:

  • The CTI index demonstrates a positive association with CVD risk in individuals with early-stage CKM syndrome.
  • CTI may be a valuable and practical tool for assessing CVD risk in this population.
  • Further research can explore CTI's role in managing CKM syndrome and preventing cardiovascular events.

Keywords:
CTICVDCardiovascular–Kidney–Metabolic syndrome

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