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Updated: May 4, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

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A novel C. elegans model for MAPT/Tau spreading reveals genes critical for endolysosomal integrity and seeded

Carl Alexander Sandhof1,2, Nicole Martin3, Jessica Tittelmeier3

  • 1Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany.

Autophagy
|August 25, 2025
PubMed

Keywords:
Alzheimer diseaseendolysosomal systemlysosomal membrane permeabilizationneurodegenerationprion-like spreadingtauopathies

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