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Published on: November 1, 2024
Arterial Stiffness and Histologically Confirmed Helicobacter pylori Infection in Young Adults
Hack-Lyoung Kim1, Dong-Hoon Kim2, Kyueng-Whan Min3
1Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
Insights
Helicobacter pylori (HP) infection is linked to increased arterial stiffness in young adults. Higher HP severity correlates with greater arterial stiffness, suggesting early detection may reduce cardiovascular risk.
Area of Science:
- Cardiovascular Health
- Gastroenterology
- Vascular Biology
Background:
- Helicobacter pylori (HP) infection is associated with systemic inflammation and vascular dysfunction.
- Limited research exists on the early cardiovascular impact of HP infection in younger populations.
- Arterial stiffness is an early indicator of cardiovascular risk.
Purpose of the Study:
- To investigate the association between histologically confirmed HP infection and arterial stiffness in young adults.
- To determine if HP infection severity correlates with the degree of arterial stiffness.
- To explore the independent association of HP infection with arterial stiffness, adjusting for confounders.
Main Methods:
- Retrospective analysis of health check-up data from 7803 participants.
- Inclusion of young adults aged 19-39 years with confirmed HP infection via gastric biopsy.
- Assessment of arterial stiffness using estimated pulse wave velocity (ePWV) and Updated Sydney System (USS) scores.
Main Results:
- HP infection was present in 53.9% of participants (4289 individuals).
- HP-positive individuals exhibited significantly higher ePWV compared to HP-negative individuals (6.66 ± 0.60 vs. 6.33 ± 0.58 m/s; p < 0.001).
- A positive correlation was found between USS score and ePWV (p < 0.001), with severe HP infection associated with a 3.87-fold increased likelihood of elevated ePWV.
Conclusions:
- HP infection is independently associated with increased arterial stiffness in young adults.
- Greater severity of HP infection, as indicated by USS score, correlates with higher ePWV levels.
- Early detection and management of HP infection may be crucial for mitigating long-term cardiovascular risk in young individuals.
Abstract:
Helicobacter pylori (HP) infection has been linked to systemic inflammation and vascular dysfunction, potentially contributing to arterial stiffness. Research in younger populations is limited, highlighting the need to explore its early cardiovascular impact. This study investigated the association between histologically confirmed HP infection and arterial stiffness. Data were retrospectively analyzed from a cohort of adults who underwent health check-ups and gastric mucosal biopsies to confirm HP infection. A mong them, young adults aged 19-39 years were included in the analysis. Arterial stiffness was assessed using estimated PWV (ePWV), which was calculated using age and mean arterial pressure according to validated equations. Among 7803 participants, 4289 (53.9%) tested positive for HP. ePWV was significantly higher in HP-positive individuals (6.66 ± 0.60 vs. 6.33 ± 0.58 m/s; p < 0.001), with a linear increase observed across HP severity levels (analysis of variaungnce p < 0.01). A positive correlation was identified between the Updated Sydney System (USS) score and ePWV (p < 0.001). Multiple linear regression analysis demonstrated an independent association between USS score and ePWV after adjusting for confounders. Logistic regression analysis showed that severe HP infection was associated with a markedly higher likelihood of elevated ePWV (odds ratio, 3.87; 95% CI. 3.25-4.60; p < 0.001). HP infection was independently associated with increased arterial stiffness in young adualts, with greater infection severity linked to higher ePWV levels. Early detection may help reduce long-term cardiovascular risk.
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