Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

293
Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
293

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Fluoxetine Brain Concentrations, Plasma Exposure, and Neurometabolism on Depressive and Anxiety Symptoms in Adolescents: A Multimodal Fluorine and Proton Magnetic Resonance Spectroscopy Study.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Global Evidence on Helmet Use and Misuse: A Public Health Perspective on Prevalence, Determinants and Barriers.

Health science reports·2026
Same author

Central Nervous System Iron Content in Pediatric CKD.

Kidney international reports·2025
Same author

Bifidobacterium's Influential Role in the Battle Against Obesity: Going Beyond Probiotics.

Probiotics and antimicrobial proteins·2025
Same author

Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation.

Neurology international·2025
Same author

Three-Dimensional Diffusion-Weighted Multi-Slab MRI With Slice Profile Compensation Using Deep Energy Model.

ArXiv·2025
Same journal

Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.

Magnetic resonance in medicine·2026
Same journal

Suppression of Oscillation and Ghosting in RF-Spoiled Gradient-Echo-Based Dynamic Imaging.

Magnetic resonance in medicine·2026
Same journal

A Simple, Dynamic Geometric Phantom for MRI and CT Reconstruction Pipelines: Beyond Shepp-Logan.

Magnetic resonance in medicine·2026
Same journal

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B<sub>0</sub> Field Gradients.

Magnetic resonance in medicine·2026
Same journal

A Comparison of Tissue Property Values Estimated Using Conventional Cardiac MRF and MT-Cardiac MRF.

Magnetic resonance in medicine·2026
Same journal

Dependence of the Extra-Cellular Diffusion Coefficient on the Fractions of Neurites and Cell Bodies in Gray Matter.

Magnetic resonance in medicine·2026
See all related articles

Related Experiment Video

Updated: Sep 10, 2025

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

10.4K

Advanced microstructure imaging at high b-values and high resolution combining ultra-high performance gradient

Chu-Yu Lee1, Reza Ghorbani2, Mahsa Rajabi2

  • 1Department of Radiology, University of Iowa, Iowa City, Iowa, USA.

Magnetic Resonance in Medicine
|August 25, 2025
PubMed
Summary
This summary is machine-generated.

Accelerated 3D multi-slab diffusion-weighted imaging (3D-msDWI) with high-performance gradients enables high-resolution brain microstructure modeling in under 15 minutes. This advanced technique supports in-vivo human studies with improved accuracy and efficiency.

Keywords:
3D k‐space acceleration3D multi‐slab diffusion‐weighted imagingMAGNUScompartment modelshigh‐performance gradientsmodel‐based deep learningmulti‐dimensional diffusion encodingplug‐and‐play priorsq‐space trajectory imaging (QTI)

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.4K
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.4K

Related Experiment Videos

Last Updated: Sep 10, 2025

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
17:16

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

10.4K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.4K
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.4K

Area of Science:

  • Neuroimaging
  • Diffusion MRI
  • Biophysical Modeling

Background:

  • 3D multi-slab diffusion-weighted acquisition (3D-msDWI) offers optimal SNR-efficiency but is limited by long volume acquisition times (VAT).
  • High-performance gradients (HPG) allow for shorter echo times at high b-values, crucial for advanced diffusion MRI.
  • Advanced microstructure modeling requires high-resolution data, which has been challenging to acquire efficiently.

Purpose of the Study:

  • To demonstrate the extended capabilities of 3D-msDWI on HPG systems for high-resolution in-vivo human brain microstructure modeling.
  • To showcase the feasibility of accelerated 3D-msDWI for advanced diffusion studies at 1mm isotropic resolution.

Main Methods:

  • Utilized optimized 3D k-space under-sampling to substantially reduce VAT for 3D-msDWI.
  • Employed HPG systems (>200 mT/m, >300 T/m/s) for shorter echo times and high b-values (up to 6000 s/mm²).
  • Reconstruction involved a navigator-based, motion-compensated, regularized, iterative model-based algorithm for a 3-shell, 66-direction acquisition.

Main Results:

  • Generated whole-brain parametric maps of a three-compartment model at 1mm isotropic resolution in under 15 minutes.
  • Reported intra-axonal diffusivities and volume fractions with coefficients of variation <10% across subjects in key white matter regions.
  • Validated quantified values against standard single-diffusion and multi-dimensional q-trajectory encoding acquisitions.

Conclusions:

  • The accelerated 3D-msDWI framework, leveraging HPG and advanced reconstruction, effectively supports whole-brain, high-resolution microstructure modeling.
  • This approach enhances the feasibility of in-vivo human diffusion studies requiring detailed microstructural information.