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Related Experiment Videos

Renal scleroderma, value of clinical markers.

C Mallée, K A Meijers, A Cats

    Clinical and Experimental Rheumatology
    |October 1, 1985
    PubMed
    Summary

    Renal scleroderma (RSc) affects 16 of 36 scleroderma patients, often presenting as hypertension. RSc significantly increases mortality risk, highlighting the need for early detection and management in scleroderma care.

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    Area of Science:

    • Nephrology
    • Rheumatology
    • Internal Medicine

    Background:

    • Scleroderma is a multisystem autoimmune disease with potential renal involvement.
    • Renal scleroderma (RSc) is a serious complication impacting patient prognosis.

    Purpose of the Study:

    • To retrospectively investigate the incidence and clinical features of renal scleroderma (RSc) in a cohort of scleroderma patients.
    • To assess the association between RSc and patient mortality.

    Main Methods:

    • Retrospective analysis of 36 consecutive scleroderma patients over 12 years.
    • Defined RSc by presence of hypertension (SBP ≥ 95 mmHg), proteinuria (≥ 0.5 g/24 hr), or impaired creatinine clearance (≤ 50 ml/min).

    Main Results:

    • 16 out of 36 patients met criteria for RSc.
    • Hypertension was the most common feature (15/16 patients), with two forms: early malignant hypertension (5 patients, 4 with renal failure) and later moderate hypertension (10 patients).
    • Proteinuria was exclusively observed with malignant hypertension. Renal impairment occurred in 7 patients. The mortality rate was significantly higher in patients with RSc (10/14 deaths) compared to those without RSc (4/20 deaths).

    Conclusions:

    • Renal scleroderma is a frequent and severe complication of scleroderma.
    • Malignant hypertension is a key indicator of poor renal outcomes in RSc.
    • RSc is associated with a substantially increased risk of mortality in scleroderma patients.

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