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Virus in infectious uveitis: bibliometric analysis and a clinical study
Junhui Shen1,2, Jinfeng Kong1,2, Yufeng Xu1,2
1Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Frontiers in Microbiology
|August 25, 2025
Summary
Research shows a growing interest in viral uveitis, with metagenomic next-generation sequencing (mNGS) proving highly effective for pathogen detection in intraocular fluid. This advanced technique offers a significant improvement over traditional culture methods for diagnosing infectious uveitis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Molecular Biology
Background:
- Viral uveitis research has surged due to detection technology advancements.
- Understanding the epidemiology and etiology of infectious uveitis is crucial.
Purpose of the Study:
- To conduct a bibliometric analysis of viral and infectious uveitis literature.
- To retrospectively evaluate infectious uveitis cases using advanced sequencing techniques.
Main Methods:
- Bibliometric analysis of publications from 1990-2021.
- Retrospective study of 73 patients with suspected infectious uveitis.
- Metagenomic next-generation sequencing (mNGS) and microbiological culture of intraocular fluid samples.
Main Results:
- Publication trends show a steady increase, peaking in 2021, with the US as a leading contributor.
- Research focus shifted from serodiagnosis to intraocular fluid testing.
- mNGS achieved a 73.97% positivity rate, identifying diverse pathogens, significantly outperforming culture (3.45%). Common pathogens included Varicella-Zoster Virus, Epstein-Barr Virus, and bacteria.
Conclusions:
- Viruses are primary causes of infectious uveitis, demanding continued research into types and diagnostics.
- Metagenomic next-generation sequencing (mNGS) is highly effective for diagnosing infectious uveitis by detecting various pathogens in intraocular fluid.
