Exploring the relationship between dietary index for gut microbiota and cognitive function

Significant correlations exist between gut microbiota, dietary habits, and cognitive function; the objective of this research was to evaluate the correlation between the dietary index for gut microbiota (DI-GM) and cognitive performance. The primary objective of this study was to evaluate the strength and direction of the association between Dietary Index for Gut Microbiota (DI-GM) scores and cognitive performance among older adults, and to further explore whether a dose-response relationship exists, thereby informing potential dietary strategies for cognitive risk stratification.

Complete DI-GM and cognitive function evaluation data for older adults were taken from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) database. Cognitive function was assessed by standardized test scales. The weighted linear regression models were used to examine the association between DI-GM and cognitive function. Restricted cubic spline and threshold analysis evaluated the existence of non-linear correlations among variables. Subgroup studies were conducted to evaluate the consistency of the connection across different demographics.

The outcome analysis showed that among the 2,207 participants, there was a positive and statistically significant relationship between higher DI-GM scores and scores of beneficial gut microbiota and total scores of cognitive functions (β = 0.03, 95% CI: 0.01-0.05, P = 0.034). Both RCS and threshold analyses confirmed the linear correlation between DI-GM and beneficial gut flora and total scores of cognitive functions (P for non-linear > 0.05). Additionally, our study demonstrated that the correlation between DI-GM and total scores of cognitive functions was maintained in subgroup analyses (P for interaction > 0.05).

The findings of the study indicated that DI-GM profoundly impacts cognitive performance, which suggests that dietary modifications based on DI-GM may help lower the level of cognitive impairment in the elderly, but further high-caliber research is required to elucidate the precise processes and application modalities, and to provide more effective strategies for improving cognitive function in the elderly.