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Related Experiment Video

Updated: Sep 10, 2025

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Exploring the relationship between dietary index for gut microbiota and cognitive function.

Changhu Sun1, Tingting Tan1, Zeping Chen1,2

  • 1Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Frontiers in Nutrition
|August 25, 2025
PubMed
Summary

Higher scores on the Dietary Index for Gut Microbiota (DI-GM) correlate with better cognitive function in older adults. Dietary strategies targeting gut health may help reduce cognitive decline.

Keywords:
NHANEScognitive functioncross-sectional studydietary index for gut microbiotaolder people

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Area of Science:

  • Nutrition Science
  • Neuroscience
  • Microbiome Research

Background:

  • Gut microbiota, dietary habits, and cognitive function are interconnected.
  • The Dietary Index for Gut Microbiota (DI-GM) is a tool to assess diet quality related to gut health.
  • Understanding this link is crucial for developing strategies to maintain cognitive health in aging populations.

Purpose of the Study:

  • To evaluate the association between the DI-GM and cognitive performance in older adults.
  • To determine the strength and direction of this relationship.
  • To explore potential dose-response effects and inform dietary interventions for cognitive health.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014.
  • Assessed cognitive function using standardized tests.
  • Employed weighted linear regression, restricted cubic splines, and threshold analyses to examine associations and non-linear correlations.

Main Results:

  • A significant positive correlation was found between higher DI-GM scores and cognitive function (β = 0.03, P = 0.034).
  • Analyses confirmed a linear relationship between DI-GM and cognitive function.
  • This association remained consistent across various demographic subgroups.

Conclusions:

  • The DI-GM is a significant factor influencing cognitive performance in older adults.
  • Dietary modifications guided by DI-GM may offer a strategy to mitigate cognitive impairment.
  • Further research is needed to understand mechanisms and optimize dietary interventions for cognitive enhancement.