Trichoblastoma/trichoblastic carcinoma: about two cases

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Trichoblastomas (TBs) are rare, slow-growing benign follicular tumors, primarily affecting the head and neck.
• Trichoblastic carcinoma (TC) represents the malignant counterpart of TBs.
• Both TBs and TCs share clinical and histological similarities with basal cell carcinoma (BCC), complicating diagnosis.

Observation:

• This report details two cases: a 65-year-old female with nasal TB and a 61-year-old male with nasal TC.
• Both patients underwent surgical treatment.
• Histological examination confirmed the diagnoses of TB and TC, respectively.

Findings:

• TBs are benign but can progress to aggressive TC.
• The differential diagnosis between TB/TC and BCC is challenging due to overlapping features.
• Surgical excision with clear margins is the standard treatment for these follicular tumors.

Implications:

• Accurate differentiation of TB/TC from BCC is essential for timely and appropriate management.
• Early diagnosis and treatment lead to favorable outcomes for patients with these rare follicular neoplasms.
• Further research may help establish specific diagnostic criteria and treatment guidelines for TBs and TCs.