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Related Concept Videos

Bioremediation00:46

Bioremediation

Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
Absorption of Nutrients01:19

Absorption of Nutrients

Absorption refers to taking dietary nutrients from the intestinal lumen for transportation throughout the body. After digestion in the small intestine, carbohydrates, proteins, and fats are broken down into simpler forms. These essential macronutrients and other vital substances, such as vitamins, minerals, and water, are then prepared for absorption into the bloodstream.
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
iChip01:24

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Related Experiment Video

Updated: Jul 7, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Bioresorbable scaffolds advances, challenges, and future directions.

Muhammad Farhan1, Gadeer Hasan1, Abdulaziz Sobhi1

  • 1Department of Internal Medicine, Ajman University, College of Medicine, Ajman, United Arab Emirates.

Annals of Medicine and Surgery (2012)
|August 25, 2025
PubMed
Summary

Bioresorbable vascular scaffolds (BRS) offer theoretical advantages over metallic stents but faced safety concerns. This study reviews BRS adverse events, optimization strategies, and novel manufacturing techniques to improve patient selection and scaffold design.

Keywords:
3D printingABSORB IVbioresorbable scaffoldscoronary artery diseaserestenosisstent thrombosis

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Area of Science:

  • Cardiovascular research
  • Biomaterials science
  • Medical device engineering

Background:

  • Metallic stents have limitations, prompting the development of bioresorbable vascular scaffolds (BRS).
  • The first BRS, Absorb BVS, was withdrawn due to safety concerns, despite theoretical benefits like reduced thrombosis and need for antiplatelet therapy.
  • Recent data suggest comparable long-term safety to metallic stents, yet concerns persist.

Purpose of the Study:

  • To review adverse events associated with various BRS models.
  • To explore strategies for optimizing BRS use and manufacturing.
  • To discuss novel BRS models and patient selection criteria.

Main Methods:

  • Literature review of adverse events and clinical trial data for BRS.
  • Analysis of emerging BRS manufacturing technologies, including 3D printing.
  • Evaluation of patient selection criteria for BRS implantation.

Main Results:

  • BRS models have demonstrated varied adverse event profiles.
  • 3D printing offers potential for cost-effective and customized BRS production.
  • Careful patient selection can mitigate risks like target lesion failure.

Conclusions:

  • Optimizing BRS use through patient selection and advanced manufacturing is crucial.
  • Novel BRS designs and technologies hold promise for improving cardiovascular treatment.
  • Addressing safety concerns requires continued research and development in BRS technology.