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The 2024 monkeypox outbreak in Pakistan: assessing the nation's public health preparedness

Hashir Ali Awan1, Muhammad Omaise Zafar1, Syeda Isra Tahera1

  • 1Department of Internal Medicine, Dow Medical College, Karachi, Pakistan.

Annals of Medicine and Surgery (2012)
|August 25, 2025
PubMed

Insights

The monkeypox virus (MPXV) subclade Ib is spreading globally, raising concerns due to its association with severe disease. Pakistan faces significant challenges in managing mpox due to its unprepared healthcare system.

Area of Science:

  • Virology and Public Health: Monitoring the emergence and spread of novel viral subclades.

Background:

  • Monkeypox virus (MPXV) subclade Ib, a variant of clade I, is rapidly spreading across Africa and has been detected internationally.
  • Clade I MPXV historically causes more severe disease than clade II, and subclade Ib's mutations warrant increased concern.

Discussion:

  • Pakistan's healthcare system is ill-equipped to handle a potential mpox public health emergency, exacerbated by prior crises like COVID-19 and recent floods.
  • Sustained human-to-human transmission of MPXV in Pakistan could lead to a significant public health crisis.

Key Insights:

  • Pakistan is among the first non-African nations to report mpox cases amid a global health alert.
  • The emergence of MPXV subclade Ib highlights the need for rapid international response and surveillance.

Outlook:

  • A coordinated national strategy and international collaboration are crucial for mitigating the mpox crisis in Pakistan.
  • Strengthening healthcare infrastructure and preparedness is essential to combatting future viral outbreaks.
Keywords:
WHOclade Ibepidemicmonkeypoxvirus

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