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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Selective Mono- and Diamination of 2,6-Dibromopyridine for the Synthesis of Diaminated Proligands
Alexander S Underwood1, Mark A Botrous1, Nate T Lobb1
1Department of Chemistry, Furman University, Greenville, South Carolina 29613, United States.
Abstract:
Selective mono- or diaminations of 2,6-dibromopyridine were performed using microwave irradiation with water as solvent in 2-2.5 h. The only significant difference between the syntheses was the inclusion of K2CO3 as base and CuI/DMPAO catalyst for the diaminations. The mono- and diaminations had approximately 7 and 2 g isolated yields, respectively. The monoaminated bromopyridines were attached to a TREN scaffolding molecule yielding novel ligands to support extended metal atom chain complexes.
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