Related Experiment Video

Updated: Sep 10, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

488

Association between Life's Crucial 9 and psoriatic arthritis in U.S. adults: a cross-sectional study

Jiefeng Jiang1,2, Lyuxin Guan3, Ziqin Gan4

  • 1The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Frontiers in Medicine
|August 25, 2025
PubMed

Insights

Higher cardiovascular health, measured by Life's Crucial 9 (LC9), is linked to a lower risk of psoriatic arthritis (PsA). Improving LC9 scores may help reduce PsA prevalence.

Area of Science:

  • Cardiology
  • Rheumatology
  • Public Health

Background:

  • Psoriatic arthritis (PsA) is associated with increased cardiovascular disease (CVD) risk.
  • The relationship between Life's Crucial 9 (LC9) and PsA prevalence is not well-understood.
  • LC9 offers a comprehensive assessment of cardiovascular health (CVH).

Purpose of the Study:

  • To investigate the association between LC9 scores and PsA prevalence.
  • To explore the implications of cardiovascular health on psoriatic arthritis risk.

Main Methods:

  • Cross-sectional, population-based study using NHANES data (2005-2014) from 7,531 US adults.
  • LC9 scores categorized into low, moderate, and high CVH levels.
  • Logistic regression and restricted cubic splines analyzed the association between LC9 and PsA.

Main Results:

  • Moderate to high CVH levels were associated with a significantly lower likelihood of PsA.
  • A 10-point increase in LC9 score correlated with a 32% reduction in PsA odds.
  • No significant association found between LC9 and psoriasis without arthritis (PsC).

Conclusions:

  • LC9 scores and their components are inversely correlated with PsA risk.
  • Adherence to LC9 lifestyle recommendations may lower PsA prevalence.
Abstract

Keywords:
Life’s Crucial 9NHANEScardiovascular healthpsoriasispsoriatic arthritis

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