Related Experiment Video
Updated: Sep 10, 2025
Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
Published on: May 30, 2025
Evaluation of Ki-67 expression levels in esophageal squamous cell carcinoma using dual-energy CT quantitative
Jing Sun1, Yong-Ying Huang2, Tao Lu1
1Department of Radiology, Clinical Oncology School of Fujian Medical University and Fujian Cancer Hospital (Fujian Branch of Fudan University Affiliated Cancer Hospital), Fuzhou, Fujian, China.
Aim:
This study investigates the use of dual-energy computed tomography (DECT) quantitative parameters to assess Ki-67 expression levels in esophageal squamous cell carcinoma (ESCC).
Methods:
A total of 57 ESCC patients who underwent dual-phase DECT scans were included. Key parameters measured were iodine concentration (IC), water concentration (WC), normalized iodine concentration (NIC), spectral Hounsfield unit curve slope (λHu), and effective atomic number (Zeff). Univariate and multivariate analyses identified factors associated with Ki-67 expression levels.
Results:
Results showed that high Ki-67 expression correlated with significantly higher Zeff and IC values in the venous phase (VP) (P = 0.047 and P = 0.049, respectively; AUC = 0.67 for both), and lower WC in the arterial phase (AP) (P = 0.021; AUC = 0.70). Multivariate analysis revealed that IC in VP and WC in AP were independent predictors of Ki-67 overexpression. The combination of these two parameters yielded an AUC of 0.78 for predicting Ki-67 overexpression, with 68.3% sensitivity, 87.5% specificity, and 73.7% accuracy.
Conclusions:
DECT parameters demonstrate potential for non-invasive Ki-67 status detection in ESCC, offering valuable insights for clinical diagnosis and prognosis.
