Related Experiment Video
Updated: Sep 10, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Physicians' information-seeking, appraising, and clinical decision-making practices for drug prescriptions: an
Akhi Nath1, Julien Meyer2, Mathieu Templier3
1akhi.nath@torontomu.ca, Toronto Metropolitan University, Canada.
Objective:
The purpose of this study is to understand the process of physicians' evidence-based clinical decision-making for new drug prescriptions.
Methods:
Eleven semi-structured interviews were conducted, and thematic coding was used for data analysis.
Results:
Several findings emerged. First, point-of-care information seeking focuses more on accessible and easy-to-use sources, such as medical websites, while out-of-practice searches encompass broader sources such as printed sources and extended networks. Medical websites are becoming preferred sources of information. Second, critical appraisal of information is performed passively by using pre-appraised information sources and referring to professional networks. Third, professional networks (i.e., specialists and senior colleagues) remain essential throughout the process and are pivotal for the decision to change prescription practices.
Conclusions:
Medical information systems that facilitate immediate access to summarized reliable evidence and feature real-time connectivity to the communities of practice can be an effective strategy for improving physicians' evidence-based practice for new drug prescriptions.
Related Concept Videos
Drug Abuse and Addiction: Pharmacological Phenomena
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Drug Administration and Therapy Phases: Overview
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Biopharmaceutics and Pharmacokinetics: Overview
Structure-Activity Relationships and Drug Design
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

