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Autonomous 'self-driving' laboratories: a review of technology and policy implications
Alexander V Tobias1, Adam Wahab1
1Department of Biotechnology and Life Sciences, The MITRE Corporation, McLean, VA, USA.
Royal Society Open Science
|August 25, 2025
Summary
Self-driving laboratories (SDLs), integrating artificial intelligence (AI) and automation, are transforming scientific research. While offering advancements, they raise patent, safety, and workforce concerns that require careful consideration.
Area of Science:
- Chemistry
- Materials Science
- Biological Sciences
Background:
- Emerging technology of autonomous, 'self-driving' laboratories (SDLs) combining artificial intelligence (AI) and laboratory automation.
- SDLs automate nearly the entire scientific method, from hypothesis generation to data analysis and conclusion updating.
- 'Cloud labs' provide subscription-based remote access to experimental capabilities, enabling AI-directed experiments.
Purpose of the Study:
- To review and provide perspective on the emerging technology of SDLs.
- To explore the implications of SDLs for scientific research, patent law, safety, security, and the workforce.
- To assess the potential societal impacts of AI-driven scientific discovery.
Main Methods:
- Review of current literature and capabilities of SDLs.
- Analysis of AI's role in automating the scientific method.
- Examination of legal, ethical, and societal challenges posed by SDLs.
Main Results:
- SDLs are increasingly capable of automating the full scientific method.
- AI-driven science presents challenges for patent law, as only human inventors are recognized.
- SDLs raise safety, security, and workforce concerns, though deemed surmountable.
- Analysis indicates potential displacement of some scientific roles but creation of new opportunities.
Conclusions:
- SDLs represent a significant advancement in scientific research automation.
- Addressing patent, safety, security, and workforce implications is crucial for SDLs' responsible development.
- Proactive measures, human accountability, and cybersecurity are essential for managing SDL risks.
- The integration of AI in laboratories is poised to reshape the scientific landscape and labor market.

